Insider Buying and Selling - Ra Capital Management, L.P.

Fulcrum Therapeutics, Inc. - FULC

10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

0

$0

0 Shares

Indirect Sells

1

($58.38) M

-4,175,139 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
12/08/2025	12/10/2025	Sell	-4,175,139 @ $13.98	($58,377,021)	6,053,960 (-40.82%)	Indirect - See footnotes

Sionna Therapeutics, Inc. - SION

Director 10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

0

$0

0 Shares

Indirect Sells

7

($21.46) M

-540,277 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
11/21/2025	11/24/2025	Sell	-25,183 @ $39.50	($994,728)	159,033 (-13.67%)	Indirect - See footnotes
11/20/2025	11/24/2025	Sell	-5,133 @ $40.13	($205,975)	166,642 (-2.99%)	Indirect - See footnotes
11/19/2025	11/19/2025	Sell	-47,442 @ $40.01	($1,898,173)	168,193 (-22.00%)	Indirect - See footnotes
11/18/2025	11/19/2025	Sell	-6,922 @ $39.57	($273,904)	182,527 (-3.65%)	Indirect - See footnotes
11/17/2025	11/19/2025	Sell	-81,987 @ $40.59	($3,328,081)	184,619 (-30.75%)	Indirect - See footnotes
10/28/2025	10/28/2025	Sell	-62,610 @ $39.58	($2,478,104)	209,391 (-23.02%)	Indirect - See footnotes
10/24/2025	10/28/2025	Sell	-311,000 @ $39.50	($12,284,500)	219,867 (-58.58%)	Indirect - See footnotes

Wave Life Sciences Ltd. - WVE

Director 10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

1

$6,688

1,000 Shares

Indirect Sells

0

$0

0 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
11/13/2025	11/14/2025	Buy	1,000 @ $6.69	$6,688	18,203,009 (0.01%)	Indirect - See footnotes

Vor Biopharma Inc. - VOR

Director 10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

0

$0

0 Shares

Indirect Sells

11

($33.72) M

-1,202,649 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
10/30/2025	10/30/2025	Sell	-24,579 @ $25.12	($617,424)	779,652 (-3.06%)	Indirect - See footnotes
10/29/2025	10/30/2025	Sell	-251,518 @ $25.22	($6,343,284)	804,231 (-23.82%)	Indirect - See footnotes
10/28/2025	10/30/2025	Sell	-124,311 @ $27.42	($3,408,230)	1,055,749 (-10.53%)	Indirect - See footnotes
10/27/2025	10/27/2025	Sell	-90,941 @ $28.12	($2,557,261)	1,180,060 (-7.16%)	Indirect - See footnotes
10/24/2025	10/27/2025	Sell	-53,345 @ $28.01	($1,494,193)	1,271,001 (-4.03%)	Indirect - See footnotes
10/23/2025	10/27/2025	Sell	-76,880 @ $28.01	($2,153,409)	1,324,346 (-5.49%)	Indirect - See footnotes
10/21/2025	10/22/2025	Sell	-25,027 @ $28.11	($703,509)	1,401,226 (-1.75%)	Indirect - See footnotes
10/20/2025	10/22/2025	Sell	-92,023 @ $29.67	($2,730,483)	0 (-100.00%)	Indirect - See footnotes
10/17/2025	10/17/2025	Sell	-260,859 @ $29.39	($7,667,444)	15,104 (-94.53%)	Indirect - See footnotes
10/16/2025	10/17/2025	Sell	-151,803 @ $29.45	($4,470,604)	57,920 (-72.38%)	Indirect - See footnotes
10/15/2025	10/17/2025	Sell	-51,363 @ $30.55	($1,569,313)	82,836 (-38.27%)	Indirect - See footnotes

Pepgen Inc. - PEPG

Director 10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

1

$30.00 M

9,375,000 Shares

Indirect Sells

0

$0

0 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
09/26/2025	09/30/2025	Buy	9,375,000 @ $3.20	$30,000,000	18,554,273 (102.13%)	Indirect - See footnotes

Mineralys Therapeutics, Inc. - MLYS

Director

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

2

$47.50 M

2,472,766 Shares

Indirect Sells

0

$0

0 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
09/04/2025	09/08/2025	Buy	1,176,470 @ $25.50	$29,999,985	5,456,521 (27.49%)	Indirect - See footnotes
03/13/2025	03/17/2025	Buy	1,296,296 @ $13.50	$17,499,996	4,280,051 (43.45%)	Indirect - See footnotes

Cidara Therapeutics, Inc. - CDTX

Director 10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

1

$100.00 M

2,272,727 Shares

Indirect Sells

0

$0

0 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
06/26/2025	06/30/2025	Buy	2,272,727 @ $44.00	$99,999,988	3,365,523 (207.97%)	Indirect - See footnotes

Tyra Biosciences, Inc. - TYRA

Director 10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

6

$15.32 M

1,561,335 Shares

Indirect Sells

0

$0

0 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
06/16/2025	06/16/2025	Buy	11,813 @ $10.13	$119,666	10,259,291 (0.12%)	Indirect - See footnotes
06/13/2025	06/16/2025	Buy	120,167 @ $10.20	$1,225,703	10,247,478 (1.19%)	Indirect - See footnotes
06/12/2025	06/16/2025	Buy	31,307 @ $10.20	$319,331	10,127,311 (0.31%)	Indirect - See footnotes
06/09/2025	06/11/2025	Buy	186,850 @ $10.19	$1,904,002	10,096,004 (1.89%)	Indirect - See footnotes
06/05/2025	06/06/2025	Buy	213,334 @ $10.04	$2,141,873	9,909,154 (2.20%)	Indirect - See footnotes
06/04/2025	06/06/2025	Buy	997,864 @ $9.63	$9,609,430	9,695,820 (11.47%)	Indirect - See footnotes

Werewolf Therapeutics, Inc. - HOWL

Director 10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

3

$487,188

536,426 Shares

Indirect Sells

0

$0

0 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
05/14/2025	05/14/2025	Buy	162,539 @ $0.98	$159,288	6,237,482 (2.68%)	Indirect - See footnotes
05/13/2025	05/14/2025	Buy	52,974 @ $0.98	$51,915	6,074,943 (0.88%)	Indirect - See footnotes
05/12/2025	05/14/2025	Buy	320,913 @ $0.86	$275,985	6,021,969 (5.63%)	Indirect - See footnotes

Janux Therapeutics, Inc. - JANX

Director 10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

3

$25.34 M

824,041 Shares

Indirect Sells

0

$0

0 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
03/07/2025	03/07/2025	Buy	110,206 @ $31.02	$3,418,590	10,141,287 (1.10%)	Indirect - See footnotes
03/06/2025	03/07/2025	Buy	372,093 @ $30.78	$11,453,023	10,031,081 (3.85%)	Indirect - See footnotes
03/05/2025	03/07/2025	Buy	341,742 @ $30.64	$10,471,352	9,658,988 (3.67%)	Indirect - See footnotes

89Bio, Inc. - ETNB

Director 10% owner

Direct Buys

0

$0

0 Shares

Direct Sells

0

$0

0 Shares

Indirect Buys

1

$50.00 M

5,714,285 Shares

Indirect Sells

0

$0

0 Shares

Monthly Values

Transaction	Filed	Type	Shares @ Price	Value	Balance ( Change % )	Ownership
01/30/2025	02/03/2025	Buy	5,714,285 @ $8.75	$49,999,994	19,554,319 (41.29%)	Indirect - See Footnotes

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Ra Capital Management, L.P.

Direct Buys

0

Direct Sells

0

Indirect Buys

0

Indirect Sells

1

Monthly Values

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Direct Buys

0

Direct Sells

0

Indirect Buys

0

Indirect Sells

7

Monthly Values

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Direct Buys

0

Direct Sells

0

Indirect Buys

1

Indirect Sells

0

Monthly Values

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Direct Buys

0

Direct Sells

0

Indirect Buys

0

Indirect Sells

11

Monthly Values

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Direct Buys

0

Direct Sells

0

Indirect Buys

1

Indirect Sells

0

Monthly Values

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Direct Buys

0

Direct Sells

0

Indirect Buys

2

Indirect Sells

0

Monthly Values

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Direct Buys

0

Direct Sells

0

Indirect Buys

1

Indirect Sells

0

Monthly Values

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Direct Buys

0

Direct Sells

0

Indirect Buys

6

Indirect Sells

0