Insider Buying and Selling - SYRE

Transaction	Filed	Name	Type	Shares @ Price	Value	Balance change		Ownership
06/01/2026 10b5-1	06/03/2026	Turtle Cameron Chief Executive Officer CEO Director	Sell	-15,000 @ $70.43	($1,056,486.02)	597,540	(-2.45%)	Direct
05/08/2026 10b5-1	05/08/2026	Henderson Michael Thomas Director	Sell	-80,000 @ $74.40	($5,952,050.43)	88,606	(-47.45%)	Direct
05/01/2026 10b5-1	05/01/2026	Turtle Cameron Chief Executive Officer CEO Director	Sell	-15,000 @ $71.37	($1,070,507.00)	612,540	(-2.39%)	Direct
04/01/2026 10b5-1	04/03/2026	Turtle Cameron Chief Executive Officer CEO Director	Sell	-15,000 @ $49.33	($739,912.32)	627,540	(-2.33%)	Direct
03/02/2026 10b5-1	03/03/2026	Turtle Cameron Chief Executive Officer CEO Director	Sell	-15,000 @ $42.19	($632,866.00)	642,540	(-2.28%)	Direct
02/02/2026 10b5-1	02/04/2026	Turtle Cameron Chief Executive Officer CEO Director	Sell	-15,000 @ $32.80	($492,045.15)	657,540	(-2.23%)	Direct
01/02/2026 10b5-1	01/06/2026	Turtle Cameron Chief Executive Officer CEO Director	Sell	-15,000 @ $30.68	($460,134.12)	671,907	(-2.18%)	Direct
12/01/2025 10b5-1	12/03/2025	Turtle Cameron Chief Executive Officer CEO Director	Sell	-15,000 @ $29.02	($435,355.50)	686,907	(-2.14%)	Direct
11/03/2025 10b5-1	11/05/2025	Turtle Cameron Chief Executive Officer CEO Director	Sell	-45,000 @ $23.33	($1,049,777.85)	701,907	(-6.02%)	Direct
09/02/2025	09/03/2025	Burrows Scott L Chief Financial Officer CFO	Sell	-18,428 @ $16.26	($299,639.28)	97,994	(-15.83%)	Direct

Spyre Therapeutics, Inc. - SYRE